.Nature Medicine, Released online: 18 September 2024 doi:10.1038/ s41591-024-03300-3Genomic and epidemiologic evaluations revealed that an unfamiliar reassortant popular lineage of the Oropouche infection, which has been actually circulating in the western side Amazon area of Brazil for about a decade, is actually related to the recent human episodes between 2022 as well as 2024.